Best CBD for Pain

Though people have used hemp for medical purposes–including pain relief–for centuries, it has been largely ignored by modern medicine until fairly recently.

However, many people who have used cannabis over the decades to help with their chronic pain are finally starting to be taken seriously, and several new clinical studies have confirmed that cannabidiol (CBD) does indeed reduce pain and inflammation in the human body. This is why we’ve come up with a list of the best CBD for pain for those who may be new to the world of CBD. 

In addition, thanks to the 2018 Farm Bill and new FDA regulations, you can now buy CBD over the counter in any state. With many companies now trying to cash in on the CBD enterprise, it’s up to you, the consumer, to determine which products truly are safe and effective. Our guide to the best CBD for pain is also here to help with making sure the right products get your time, attention, and promotion. 

The Top 10 Best CBD for Pain Relief

With so many CBD products now available on the market, it can be hard to narrow down the list of the best CBD for pain to just a few options. However, the products we have selected have consistently received high reviews from consumers like you who use CBD for pain management. All of the brands we list here use organic, non-GMO hemp, have been tested and verified by third-party laboratories, and can be shipped anywhere in the United States.

Read on for our list of the top 10 best CBD for pain relief!

1. Plus CBD

Plus CBD prides itself on being the top-selling hemp oil brand in the natural product industry. They’re #1 for good reason. These guys put their money where their mouth is, and have funded some of the first clinical studies into the safety and efficacy of CBD oil. They also were the first to study CO2 extraction, an environmentally-friendly method for extracting CBD oil which doesn’t break down the vitamins and nutrients that can be damaged by other extraction methods. 

After they published their findings, Plus CBD’s oil, obtained by CO2 extraction, was granted a “Generally Recognized As Safe” (GRAS) status by the FDA. Simply put, they have the research to back up their CBD benefits.

2. NuLeaf Naturals

NuLeaf Naturals’ CBD oil is a favorite of many because it gives you everything you could want from a CBD product. For starters, their hemp oil is full-spectrum and contains several other cannabinoids besides CBD, including cannabinol (CBN), cannabichromene (CBC), and cannabigerol (CBG). The oil is extracted using CO2 extraction methods and is also guaranteed to be free from pesticides, heavy metals, and other toxins.

3. CBDistillery

If you’re looking for more than just CBD oil, CBDistillery is a great company to check out. CBDistillery offers a plentiful range of CBD products you can try, including CBD tinctures, CBD capsules, and CBD creams. They also offer CBD isolates which you can add to home-made foods or beverages of your choice. One of CBDistillery’s greatest selling points is their price value, with all their CBD products offered at a very reasonable price!

4. MedTerra

MedTerra has pain-relief products for both you and your pet! These come as gummies or dropper bottles, which are easy to give to cats, dogs, and other furry creatures for arthritis and other types of pain. 

For humans, MedTerra offers tinctures, creams, and gel capsules containing either CBD on its own or in combination with other beneficial ingredients. For example, if your pain has been making it difficult to sleep, you can try their CBD plus melatonin for relief as well as a better night’s rest.

5. cbdMD

For first-time CBD users, cbdMD is a great place to start. Their CBD oils come in a range of dosages, so you can try out a low dose first then work your way up as needed. cbdMD also has a helpful first-time user guide on their webpage if you are unsure about how to start on your own. Also, if you’re an experienced user and want to try something new, they have a great variety of different CBD products available, from topicals to vape oils, and even CBD bath bombs. In addition, cbdMD offers an excellent price-per-milligram.


Perhaps you want a little variety in your CBD? The full-spectrum CBD oils and chews from FAB CBD come in a wide variety of flavors, such as citrus, mint, and vanilla. Like their hemp, these flavors come from natural, organic sources. Their topical CBD cream, great for site-specific pains and easing post-exercise aches, is also a good choice for your skin, containing aloe vera, vitamin E, and other nutrients.

7. Spruce CBD

If you need a strong kick of CBD power, Spruce is the place for you. At 2,400mg per bottle and 80mg per dropper, Spruce CBD offers the highest potency CBD you can find on the market. Their oil isn’t flavored at all, but this is only so Spruce can maximize the amount of CBD their products can hold.

8. Green Roads

Green Roads takes health and wellness seriously. The high-profile company has won awards for its CBD products and stands out for partnering with organizations like the American Red Cross to help people in need. 

In addition to their CBD oils, Green Roads has several topical CBD products, which are highly reviewed for pain relief. These contain soothing ingredients like menthol or chamomile, or heating ingredients like wintergreen, to alleviate joint pain and muscle soreness. Green Roads’ CBD also has pain-relief products specifically for first-time users and for pets.

9. Populum

If taste is important to you, then Populum is the brand to check out. Their orange-flavored full-spectrum CBD oil is one of the best tasting available, according to people who’ve tried it. They offer a range of dosages from 250mg to 1000mg per bottle, so there are options whether you are just trying it out or if you need something a bit stronger.

10. Lazarus Naturals

Lazarus Naturals’ CBD products are for people who like to pamper themselves. The flavors available for their CBD oils sound like cocktail mixes, such as “French vanilla mocha,” “chocolate mint,” and “tropical breeze.” Their topical CBD products are no different, coming in relaxing scents like lavender and cedar citrus. They also stand by their transparency, providing complete test results of all of their products right on their webpage.

Some Background on CBD and the Endocannabinoid System

Your body uses many different molecular systems to send messages between cells and tissues. One of these systems is referred to as the endocannabinoid system (ECS). The ECS helps manage many important functions in your body, including:

  • Energy
  • Sleep
  • Appetite
  • Mood
  • Pain
  • Pleasure
  • Body temperature

The ECS uses special receptors to detect chemical compounds known as cannabinoids. When cannabinoids bind to cannabinoid receptors on cells in your body, it sends a signal to create a biological response.

Some cannabinoids are produced by your own body and are called endocannabinoids. Several types of plants, including hemp, also produce cannabinoids, known as phytocannabinoids. You can also get synthetic cannabinoids, which are manufactured in a laboratory.


There are more than 100 different types of cannabinoids found in nature. The two most notable from cannabis plants that affect human health are cannabidiol (CBD) and tetrahydrocannabinol (THC). THC has psychoactive effects on the human brain and is the reason people get high from marijuana. Because it interacts with different receptors in your neurons, CBD is non-psychoactive, so you can’t get high from taking just CBD that’s free of THC.

Hemp vs. Marijuana

Hemp and marijuana are both cultivars of the same species of plant: Cannabis sativa, or the cannabis plant. Both types of plants contain CBD and THC along with a few other natural ingredients with health effects, including vitamins and minerals, dietary fiber, healthy fatty acids, terpenes, and trace amounts of other cannabinoids.

Legally, industrial hemp must contain a THC content of 0.3% or less based on its dry weight. Marijuana plants grown for recreational purposes have much more THC in them. CBD derived from hemp plants can be shipped across the entire United States, while CBD derived from marijuana can only be sold in the state it was grown in.

Synthetic CBD

Though hemp plants do contain very low amounts of THC, they are still not entirely THC-free. In fact, independent testing has found that many products claiming to contain pure CBD actually contain enough THC to cause intoxicating effects. If you want to avoid THC altogether, look for products that contain synthetic CBD, which will not have residual THC from plants in the mix.

How Does CBD Help with Pain?

Doctors and scientists don’t yet fully understand how CBD works to relieve pain. However, there are a few beneficial effects that we do know about CBD, which leads to the hypothesis that it can be potentially used as a pain reliever. 

One study found that CBD influences the neurotransmitters your nerves use to send pain signals. This makes it helpful to relieve pain from fibromyalgia.

CBD also helps control muscle spasms. This is why there are now marijuana-based prescription drugs for certain types of seizures and epilepsy. It also makes CBD helpful for controling pain from spastic muscles, which are common for individuals with multiple sclerosis (MS).

Some of the best health benefits of CBD come from its anti-inflammatory properties. Inflammation contributes to many health problems throughout the body, especially chronic pain. Using a topical CBD product–such as a transdermal patch or a salve–can reduce pain in muscles, joints, and other aching areas. CBD can even help reduce inflammation and pain from arthritis.

Side Effects of CBD

CBD is very safe to use routinely for pain relief. It does have a few possible side effects, including:

  • Dry mouth
  • Diarrhea
  • Vomiting
  • Decreased appetite
  • Weight loss
  • Drowsiness
  • Fatigue

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