Best CBD Oil for Depression

CBD oil is used by some to address issues with depression. It is commonly reported that CBD helps lessen the effects of depression and makes people who use it feel happier.

The fastest form of CBD oil to use for treating depression is vape. The CBD gets into your bloodestream faster, lowers anxiety and improves mood almost immediately.

The best form for long term, sustained relief from depression is the oral tincture taken as a daily supplement (taken both in the morning and mid to late afternoon).

About Depression

CBD Oil for Depression

Depression is an exceedingly common health issue, and the lasting effects that it has in a person’s life can be devastating. Depression is very serious; it can make it difficult for those who have it to hold down a job, hard to do the bare minimum in taking care of themselves, and quite frankly, hard to survive.

On average, there are about 3 to 4 million people battling some form of depression every day in the United States. Depression makes it difficult to participate in your life, and it takes a surprising toll on the body as well. It can lead to insomnia, a weakened immune system, headaches, and fatigue.

Effects of Chronic Depression

Chronic depression, especially when left untreated, shrinks the hippocampus. That is the area of your brain responsible for storing memories and processing emotions. This can have lasting effects like increased memory problems over time and a decreased ability to experience emotion. This can be treated, though. There are some medications on the market that help with this, and CBD oil has shown evidence of promoting neurogenesis. This can help reverse the damage of depression to the hippocampus, and also means amazing things in the medical world surrounding certain brain conditions.

Treatment for Depression

Thankfully, depression can be treated. Psychotherapy is often the first line of defense, but most people with a form of depression end up taking medication. Medicine is incredible, and we have no doubt that it has saved many lives; but, we know from experience some of the problems that can arise with long term use of antidepressants.

Serotonergic medications, like SSRIs, can lead to weight gain, insomnia, and severe sexual dysfunction. In addition, some patients have noted that their medicine seems to lose efficacy over time; this is especially frustrating because of the time and effort that goes into finding one that suits their individual needs. What truly causes depression is still being studied, but there are many things we know can help to treat it. CBD oil is one of those treatments; it has recently emerged and become a topic of conversation among clinicians, doctors, psychiatrists, and researchers.

Exercise, nutrition, and having a steady support system will always be vital keys in releasing your brain from the literal cage of depression, but CBD oil makes for a great addition to your arsenal. It is legal in all 50 states, and a variety of studies have shown it to be a viable solution in the treatment of depression.

Cannabidiol is a compound found in the cannabis plant that has been recently rocking the medical world because of its many health benefits. As early as 2014, a study was conducted and went on to show that subjects treated with CBD oil had fewer instances of depression and anxiety.

CBD Oil for Depression

CBD oil works similarly to a SSRI in its interaction with the brain. It blocks the production of serotonin to make sure that the brain is using it in the synaptic space, instead of it getting wasted. When the brain can properly use this vital neurotransmitter, you will experience a more stable mode, reduced stress, and more.

Your body also has what is called an endocannabinoid system. When this system is not working properly, functions in the body like sleep patterns, moods, energy levels, and eating habits can all be affected. CBD oil interacts directly with the endocannabinoid system to restore that balance.

The primary way that you would take CBD oil for the treatment of depression is orally. You can purchase capsules, or tinctures to do this. Capsules you would take like any other pill. Tinctures, though, you can put a few drops in your mouth and allow them to absorb before swallowing or add a few drops to your food or drink. The downside to this method is that accurate dosing is difficult because of what is called the first-pass effect. Some of the drug is going to be lost before it reaches your circulatory system, which means you may see less or slower benefits. The way to avoid this, and the second way that you can use CBD oil for depression, is by vaping.

When you vape CBD oil, you use a vaporizer or vape pen device, much like an e-cig. It warms the CBD oil, forming a vapor that you inhale. Taking CBD oil in this fashion allows it to enter your bloodstream immediately. You will see the fastest results with vaping, and because it is so direct, the dosing is the most accurate as well.

Taking care of yourself inside and out is always important, and when you have depression, we know that can be difficult. CBD oil is a great treatment avenue for you to explore.

Additional Resource on CBD Oil and Depression
How does CBD Oil improve mood?

Ranking the Best CBD Oils for Depression

The opposite of depression isn’t happiness, it’s vitality. – Andrew Solomon

When combining the number of Americans who deal with Major Depressive Disorder (MDD) and Persistent Depressive Disorder (PDD), we reach a number of 21 million, or somewhere close to 8% of the population. Many people will have a co-occuring disorder as well – usually some form of anxiety such as generalized anxiety disorder (GAD), panic disorder, social anxiety disorder, body dysmorphic disorder, sleep disorder, substance abuse, chronic pain, headaches or others. The list of ailments that are all too commonplace in the United States is extensive. Individuals may start with generalized anxiety and develop depression, or have depression and develop anxiety or simply have them occur simultaneously. In fact, depression is the leading cause of disability worldwide. According to the World Health Organization, 1 in 13 individuals on the planet suffer with depression and a million people will take their lives each year. Yet, we don’t really know what causes depression. Chemical imbalance is a myth. Some people will say depression is caused by a lack of serotonin, others will say depression is a dopamine deficiency. Recent studies reveal it’s just not that simple.

Over the past couple of years science and common wisdom caught up and studies finally started to indicate just how connected our microbiomes (the life inside of our gut) is correlated to depression and anxiety. In fact, according to a study at CalTech, it is estimated that nearly 90% of our serotonin is produced in our digestive tract. Hippocrates said this 2,000 years ago!

All disease begins in the gut.

That could be the real reason we truly don’t understand the cause of depression- these microbiomes are so unique to individuals genetics and their lifestyles. In 2014, research was pulled from the FDA and placed into the public eye thanks to the Freedom of Information Act indicating that antidepressant medications worked mostly in part to a placebo effect. These findings showed that the FDA actually hid critical information from the public! That being said, many individuals do benefit from antidepressants and should consult with their doctor with regards to staying on or tapering off of these types of medications. However, exercise, lifestyle change (especially diet) and our endocannabinoid system may have just as great if not a greater impact on depression. The endocannabinoid system is our natural biological system composed of endocannabinoids. This system helps regulate mood, pain, our appetite, and even memory. Sound familiar? Those who experience depression often describe a blighted mood, a loss of appetite, physical and mental pain, and even report forgetfulness. It’s like someone switched their “vitality” light to the off position. Today, with CBD legal in all 50 states, individuals are experiencing natural relief from what is all too often a terminal disease. Not only are individuals reporting repaired cognition, but also improved motor function. Perhaps, with better access to CBD products that attach to our endocannabinoid receptor sites, we can naturally improve our moods, minimize pain, and revitalize our lives. If you are looking to switch the vitality light back on, you may want to consider supplementing with CBD.

Whether you’re interested in CBD oil or vaping, you’ll want to find out which are the best CBD oils for depression? To select the best CBD oil, you’ll want to take into account a company’s hemp sourcing, CBD purity, and range of CBD oil products offered, as well as the range of therapeutic dosages. Because the industry is not regulated by the FDA, researching each CBD oil company is the only way to find a reputable and reliable source. To facilitate your search for the best CBD oil for depression, we’ve researched and ranked the 10 best options on the market using a number of metrics. Read up and discover the best CBD oil to support you in your fight against depression.


Range of Products Score (1/5)

  • Beginner Dosage Score: the lowest dosage available in this brand’s product
  • Experienced Dosage Score: the highest dosage available in this brand’s product
  • Delivery Method Score: the number of distinct delivery methods of CBD oil products

Cannabinoid Variant Score (1/5)

  • The range of documented cannabinoids in the brand’s products. Often achieved through different distillation methods or extraction methods utilizing the whole hemp plant.

Product Purity Score (1/5)

  • Measure of extraction method, whether a brand’s products are certified organic, and quality control testing employed by each brand.

Sourcing Score (1/5)

  • Measure of location hemp is sourced from as it relates to environmental toxins and greater cannabinoid density. Additionally, a measure of the number of chemicals used in the production of the hemp (if any).

Health Issue-Specific Factors (1/5)

  • The brand’s range of delivery methods that are particularly well suited for aiding the medical issue at hand. In the case of CBD Oil for cancer, vaping offers the fastest route for delivery, while oral drops are generally preferred by those who don’t wish to vape
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  • The brand’s range of additional herbs, vitamins, minerals, and carrier devices that are known to aid the medical issue at hand. There are many herbs commonly taken as anti-depressent supplements. These include St. John’s Wort, Milky Oats, Mimosa, Rhodiola, Lemon Balm, Saffron, and Holy Basil, any of which may be added to CBD oil preparations to enhance the product’s therapeutic effect.

The 10 Best CBD Oils for Depression

1.) Cannabidiol Life

Cannabidiol Life offers a huge variety of products. In fact, their online store has capsules, edibles, isolates, crystals, wax, dabs, salves, pet tinctures, and even infused waters. Customers require a range of selection as one size definitely doesn’t fit all when it comes to health. Users want different products to fit their specific health concerns, personal preferences, and lifestyles, and some users prefer to take advantage of multiple products, such as taking CBD capsules while at work and vaping at night. This is especially true in the case of depression which as we know has many facets. Many CBD users find that vaping CBD oil delivers the fastest results and allows them to readily monitor when they need support. Those looking to avoid smoke, may prefer an oral transmission such as a CBD tincture- this method builds over time and the general rule of dose is to start small and build with experience, and with need. All of the many Cannabidiol Life products are made from hemp which is organically grown in Colorado, with CBD is extracted through “cradling” in organic ethanol. Many of their products also include beneficial herbal compounds, such as St. John’s Wort for mood elevation and arnica to fight inflammation and pain. The best CBD for depression in their wide range of products is the Cannabidiol Life vape liquid, tinctures and capsules. Cannabidiol Life’s 250 mg CBD vape oil is available in 15 flavors and can be used orally or with their disposable vape pen.

2.) Pure Hemp Botanicals

As we mentioned earlier, CBD is not regulated by the FDA, meaning that research is key to finding a quality CBD product. Fear not when shopping at Pure Hemp Botanicals, which makes purity in their products and transparency their top priorities. The company welcomes you to view their labs through a virtual tour, and also publishes their CBD lab results directly on their site-guaranteeing quality “from soil to oil”. Their source hemp is non-GMO, and organically grown in Colorado. Pure Hemp Botanicals employs a full-spectrum extraction processes, sets purity benchmarks which exceed market standards, and incorporates synergistic botanicals into many products. One of the best CBD products for depression in their product lineup is Chamomile Lavender Hemp Tea. Lavender is a potent nervine (calms the nervous system), and chamomile supports the immune system which is often depleted when the body is depressed. The tea contains 30% organically grown industrial hemp, and is naturally caffeine free. We recommend taking the tea nightly as part of an unwinding and relaxing regime to help support you through those long exhausting days. We also recommend the company’s CBD tinctures for depression, which boast an array of plant cannabinoids and terpenes, along with antioxidants and omega-3 and -6 fatty acids. The tinctures are made from hemp seed oil and CBD in concentrations of 300 mg, 750 mg, 1500 mg, or 3000 mg per bottle.

3. Endoca

Endoca offers high quality CBD products and even runs an associated nonprofit that has a hemp seed bank, and edible plant forestry venture, as well as a meditation and healing center Not only that but the nonprofit is committed to distribute CBD to low-income families with health concerns.. This family-owned company Endoca is committed to chemical-free processing and stringent third-party testing. They are also committed to transparency, making test results available to consumers on their website. Their source hemp is organically and sustainably grown on permaculture farms in Denmark, and their products are formulated by a team of scientists, herbalists and nutritionists. Their manufacturing follows a GMP-certified (Good Manufacturing Practice) process. The best CBD for depression available through Endoca is their CBD tincture and capsules. The cold-extracted oral CBD drops have a mild flavor and contain 5-10 mg CBD per dose, along with terpenes, vitamins, ketones, amino acids, and phytonutrients to help naturally boost your mood, and overall cognitive function. The capsules are available as CBD or CBD+CBDa. The CBDa is thought to be anti-inflammatory, anti-nausea, antioxidant, and antibacterial/antimicrobial- meaning the capsules with CBDa would work well for individuals who experience pain along with their depression. Capsules are available in 300 mg or 1500 mg doses.

4. Green Roads

Green Roads World is the official CBD oil of the NFL and has been featured on ESPN, Forbes, High Times, Herb, and NBC. Not only that, but their products have been endorsed by several professional athletes. So what does that have to do with depression? For starters their organic products have the same potent healing qualities as other companies with a more holistic and wellness-focused image. Their products also feature holistic botanicals to aid in physical recovery. While that may be a top priority for athletes, physical repair can be a high priority for individuals who suffer from depression as well. When we examined depression and co-occurring disabilities we discussed how depression can take a physical toll for individuals who are incapacitated from depression and other disorders. We like Green Roads of individuals who are dealing with multiple ailments. Green Roads sources their hemp globally from certified organic farms, and subjects it to a high-pressure, low-heat CO2 extraction method. An experienced and licensed pharmacist compounds their products with pharmaceutical-grade, 99% pure cannabidiol, and cannabidiol oil. All their CBD is are third-party tested. Our top pick in their lineup for best CBD for depression is Green Roads’ CBD oil tinctures. There are offered in five concentrations: 100 mg, 250 mg, 350mg, 550 mg, 30 ml, 1000 mg, or 1500 mg of crystalline CBD isolates and cannabinoids. Additionally, their products contain no THC.

5.) Bluebird Botanicals

Bluebird Botanicals focuses on quality and purity as well as ethical business practices. They source using fair farming and labor practices in mind, sponsor charities and will grant discounts to individuals who are disabled, veterans, or low-income. Their CBD products are created with the same high standards as well. Their hemp is grown sustainably and organically in Colorado and extracted using an energy-efficient broad-spectrum extraction procedure via CO2 or alcohol extraction. Their CBD is put through third party testing for purity and potency, and Bluebird makes their product batch results available directly on their website. A number of their products include herbal additives with anti-inflammatory, antioxidant and immunity-boosting properties. With great products and great business practices, it’s not surprising that Bluebird Botanicals was recently awarded “#1 Hemp CBD Company” at the Cannabist Awards. The best CBD for depression in Bluebird Botanicals’ inventory is their vape liquid, sublingual tinctures, and capsules. The CBD oil vape liquid, has 333 mg CBD per 10 ml bottle, in a base of Vegetable Glycerin and Propylene Glycol. Those looking for acute relief will appreciate their vape liquids- when vaped the therapeutic properties of the CBD enter the bloodstream more rapidly. Bluebird’s oral CBD tinctures (aka “concentrates”) are another great choice of CBD for depression, and come in several doses and formulations. The “Classic” blend is the most simple of these: hemp extract in hemp seed oil. “Complete” has the same, plus a comprehensive mixture of raw and heated cannabinoids and steam-distilled hemp terpenes. The “Signature” blend has all of these, along with wildcrafted frankincense serratta CO2 extract, and cold pressed black seed oil, a potent antioxidant. Some individuals have reported that black seed oil is helpful with depression, anxiety, and even PTSD. All three blends are offered as regular extracts (250 mg CBD) or concentrated (1,500 mg CBD) extracts. Capsules are another great delivery method for individuals taking CBD to combat depression. Their also very travel-friendly.

6. Charlotte’s Web

The story behind Charlotte’s Web is a young girl named Charlotte Figi. Charlotte suffered from a rare seizure disorder. After years of trying modern medicine to no avail, her parents turned to a new strain of high-CBD hemp extract designed by the Stanley brothers. Charlotte made a miraculous recovery thanks to this high-CBD hemp strain and thus the name “Charlotte’s Web”. The brothers based their company of the same name around creating health-focused CBD products derived from this strain. Today, families of children with seizure disorders and other disorders may receive discounts on CW products. Charlotte’s Web is an excellent choice for any individual who is looking to turn their life around. Their hemp is grown organically and sustainably in Colorado, and put through a gentle, broad-spectrum extraction process. The best CBD products for depression offered by this company are the Charlotte’s Web oil tincture, capsules, and vape. All CW oils are available in a lucious mint chocolate and in a variety of serving sizes. The capsules are great for individuals who travel or anyone who is just more accustomed to dosing using a tablet. The company sells capsules in 15mg and 35mg doses.

7. CBD Drip

CBD Drip provides high-quality products at lower prices. Their mission appears to be accessibility, as all of their products are use-friendly and widely available in health stores, retail stores, as well as online. CBD Drip uses non-GMO and pesticide-free hemp grown in Europe and a broad-spectrum extraction method for the synergized desired “entourage effect.” Not only that, but these formulas are full of rich omega-3 and omega-6 fatty acids. The company contracts with independent labs when testing their products, and even makes the lab results available on their website. The products are priced much lower than other companies, which will be a relief to individuals who are looking to solve some critical conditions. Their best CBD for depression is their CBD oil, which is unflavored and can be used sublingually as well as vaped. This versatile oil comes in concentrations of 14.5 mg, 58 mg, 140 mg, 500 mg or 750 mg. If you prefer to steer clear of vape, you may may wish to try the CBD oil EcoDrops, a line of terpene blends formulated with specific conditions in mind. There are four blends available: Dream, Focus, Boost, and Relief. All contain 1,500 mg of active CBD, but Boost is an especially good choice for those experiencing depression, as it contains the added nervine of lavender, immune booster of Roman Chamomile, and digestive properties of clary sage (remember many issues with depression stem from issues of digestion.)

8. Kat’s Naturals

Kat’s Naturals is unique in their emphasis on synergistic compounding, as well as high-quality extraction. The company uses specific strains of hemp to address particular health concerns, bred for a particular cannabinoid profile. These are enhanced with organically and sustainably grown, therapeutic-grade, and third-party tested essential oils, formulated to address the same target issues, such as mood or immunity. Their oils are also exceptionally pure. Most companies’ CBD oils contain up to 0.3% THC (the legally-required limit, which is not enough to be psychoactive, but enough to potentially show up on a sensitive drug test). Many of the products from Kat’s Naturals, however, are 100% THC-free. That being said the “Balance” utilizes a full-spectrum extraction-method and as such will contain trace amounts of THC. The company’s source hemp is cultivated on organic Dutch farms, and processed using a critical CO2 extraction, before being blended with whole-plant organic hemp oil. The final product is rich in omega-3 and omega-6 fatty acids, linoleic acid, and alpha-linolenic acid, which boosts the immune system. To support the immune system and promote calm, a great choice of CBD for depression is “Heal”, their most popular and most potent product. This oral CBD oil tincture is blended from 1,500 mg pure CBD isolate, organic hemp seed oil, and organic peppermint essential oil, which soothes the stomach and can help combat nausea. We also love the synergistic blend found in “Relax” which contains hops yet another botanical in the Cannabaceae family that is also high in Mycrene. Mycrene is a terpene that helps regulate mood and induce a sense of calm. “Relax” is great for individuals losing sleep from depression, and for individuals who suffer from anxiety in addition to depression. Another, more fast-acting, option is their 300 mg/oz CBD CBD vape liquid, which comes in 30 ml or 15 ml bottles. Kat’s Naturals also sells complete vape kids and even a pre-filled vape pen cartridge.

9. Elixinol

Elixinol has been around since 1991. Not as a CBD oil, but as a hemp bar. And since then has made a commitment to selling hemp-based health products in a wide variety. Customer may want to try their tinctures, capsules, sprays, vape liquids, foods, or body balms. All of their products are researched by a team of medical professionals. Elixinol’s source hemp in the US, Australia, and Europe and subjected to a high pressure low temperature CO2 extraction methods. All CBD is then tested in house and by third-party impartial labs. Consumers are welcome to view lab results directly on their website. In addition, customer’s will appreciate that 5% of their purchase is donated to a charity of the customer’s choosing, with options at checkout including the research and treatment of autism, brain tumors, and wounded veterans. The best CBD items for depression in the Elixinol inventory are the company’s oral tinctures,capsules and vape pens. We also like their “X-Pen” that comes pre-loaded with 1000mg of CBD for individuals who are looking for precision when dosing. Each click of the pen delivers 15 mg of CBD. Their oral tinctures are great for individuals looking for higher doses as Elixinol offers two 3600 mg products. Individuals living in Brazil have access to their 5000 mg product.

10. 4 Corners Cannabis

4 Corners Cannabis is not about neon lights, they are all about making great products and educating the public. The company goes to great lengths to educate consumers as to the importance of the “Entourage Effect” and its role in their product formulations. The term was coined by a pair of Israeli scientists in 1998, and explains how otherwise inactive compounds present in both marijuana and hemp enhance the psychoactive and therapeutic effects of cannabis when included in preparations, producing a synergistic outcome. This is the reasoning behind the use of whole-plant, rather than ultra-refined, CBD extracts, which is a top priority for 4 Corners CBD. The company extracts its CBD through “cradling” in organic, food-grade ethanol, and tests their extracts in-house for potency. 4 Corners employs their own proprietary strain, organically cultivated on their own farm in Colorado- controlling every step of the process from seed to sale. The best CBD for depression in their product line is their vape liquid and oral tincture. The vape liquid comes in 1,000 mg per bottle, and has a mild and sweet “hash oil” flavor. These versatile drops can also be taken orally. Those who want just an oral preparation can try the CBD tincture, which comes in concentrations of 250 or 500 mg per 15 ml bottle, or 1000 mg broad-spectrum CBD per 30 ml bottle. In addition, the blend is also formulated with MCT Oil, CBD-dominant hemp oil, and anti-inflammatory Limonene (orange extract). Individuals seeking immediate relief may want to try their vape, while those looking for long lasting sustained relief may want to choose their oral tincture.