The 8 Best CBD Oils for Depression in 2023

Please Note: At Best CBD Oils we take depression and mental health very seriously, and the CBD products that are listed within this Top Nine Ranking by our hand-picked CBD manufacturers are just intended to be used with discretion as supplements to help you to maintain positive mental health. If you or someone you know is suffering from depression, we highly recommend seeking professional health first and foremost. If you would like some resources that might be beneficial for you or for someone that you know is dealing with depression, please look into the following programs:

  • The U.S. Department of Health & Human Service Substance Abuse and Mental Health Services Administration (SAMHSA)
  • The SAMHSA’s National Helpline, 1-800-662-HELP (4357) / TTY: 1-800-487-4889
  • Suicide Prevention Lifeline
  • Suicide Prevention Lifeline Hotline 1-800-273-8255 (For Deaf and Hearing Impaired: 1-800-799-4889 / En Español 1-888-628-9454)
  • National Institute of Mental Health (NIMH)
  • Veteran’s Crisis Line
  • Veteran’s Crisis Line 1-800-273-8255 (Press 1 after connecting)
Use These Page Jumps And Start Feeling More Like You!

The 8 Best CBD Oils for Depression


Medterra Good morning softgels

Medterra is a Kentucky-based CBD company that was born when a group of individuals that were passionate about the positive benefits of CBD came together with a vision to spread their love for the product and to have a positive impact on as many people and communities as possible. Medterra provides its customers with what they call “True Seed to Sale” purchases.

This is because Medterra takes responsibility for the quality of their products from the very start all the way to the final product that their customers receive. The industrial hemp that Medterra uses is grown and carefully extracted in accordance with the strict guidelines set forth by the Kentucky Department of Agriculture.

Not only that, but each product that leaves their facility also undergoes rigorous third-party laboratory testing in order to ensure both consistency and quality.

Medterra offers its customers a wide variety of different CBD-rich products, including topical creams, tinctures, soft gel capsules, and even some CBD-based pet care products. In addition to these various products that Medterra manufactures and has stringently laboratory tested for purity, safety and potency, the company is also a proud partner of the Kentucky Department of Agriculture’s (KDA) Industrial Hemp Research Pilot Program.

The Industrial Hemp Research Pilot Program (which is also known as the IHRPP) helps to ensure that industrial hemp is cultivated and manufactured in a safe, sustainable, and mindful manner. Because of this partnership, you can rest assured that the CBD products that you buy from Medterra are of very high quality and potency.

The product that we would recommend for helping to deal with depression from Medterra would be their Good Morning Soft Gels. There expertly crafted proprietary blend combines the caffeine, Vitamin B6, Vitamin B12, L-Tyrosine, and L-Theanine with 25 mg of CBD per serving. These soft gel capsules will help you get your day started right, by energizing you without giving you the jittery feeling that coffee or energy drinks often give to some people.

These soft gels will also provide you with a potent dosage of CBD, which was extracted from organic industrial hemp using a CO2 extraction process. We feel that these Good Morning Soft Gels will help those with the symptoms of depression, as many depression sufferers have a hard time waking up in the morning, and a difficult time motivating themselves in the morning as well. By being more mentally alert in the morning and getting a proper dosage of CBD into your system at the same time, we feel these soft gels could really help out a lot.

  • Product Types: Topicals, Tinctures, Capsules, and Pet Care Products
  • Our Recommended Product for Depression: Good Morning Soft Gels

Joy Organics

Joy Organics Softgels

Joy Organics is a family-owned and operated CBD company, and was founded by Joy Smith after she spent many hours researching a variety of different natural solutions and remedies to help her to find relief from her chronic pain and the struggles that she had getting restful sleep at night. She eventually found CBD, and the positive impact CBD has had on her life on her health ultimately inspired her.

Today, Joy Organics sells various high-quality CBD products that are made from organic industrial hemp that is grown right here in the United States. The facility that Joy Organics uses to process all of their products is one that is certified by the FDA and is designated as a GMP facility.

Joy Organics only uses this one facility for all of its processing, which allows for better quality control and for more consistency among all of their various products. Each product that Joy Organics sells is tested by a third-party lab and is certified to be gluten-free and to be free of other contaminants.

Everything that Joy Organics makes is made from organic and THC-free full spectrum CBD that is processed in a way to retain all of the cannabinoids and terpenes that can be found naturally in cannabis. The cultivating and processing that the CBD undergoes is done in a way so that you get all of the benefits. The company is so committed to customer satisfaction that they offer a 30-day money-back guarantee on all of their products and all of the online orders are shipped for free in the contiguous United States.

The product that Joy Organics offers that we most recommend for dealing with depression is their CBD Soft Gels with Melatonin. Each of these soft gels combines Joy Organics’ proprietary water-soluble nanoemulsion technology processed CBD with a dose of melatonin.

This mixture ensures that your body is able to make the most out of the CBD that the soft gels contain, allowing for quick and efficient access to CBD’s beneficial properties. Because these soft gels also contain a dose of melatonin, it is recommended that you take your daily dose before bed. This will allow you to get a more restful night of sleep in addition to being able to take advantage of CBD’s healing properties.

  • Product Types: Tinctures, Capsules, Topicals, Skin Care, Soft Gels, and Pet Care Products
  • Our Recommended Product for Depression: CBD Soft Gels with Melatonin


Ablis CBD Drink

Started in 2014 by founder Jim Bendis, with the help of his sons Duke and Max, Ablis makes artisanal craft CBD beverages, in addition to various other CBD products. Ablis is headquartered in Bend, Oregon, which is where they hand-craft all of their products that they have for sale.

Each of the products available through Ablis is made using all-natural, GMO-free ingredients which are expertly infused with 99+% pure, THC-free and GMP-certified CBD isolate extracted from 100% organic industrial hemp that is sustainably cultivated in the United States.

Ablis is the first CBD and cannabis beverage provider in the United States, and possibly the first CBD and cannabis beverage provider in the world.

Ablis is most well known for their delicious CBD-rich beverages, but they also make high-quality topicals, CBD crystals and concentrates. All of the CBD products that are available through Ablis contain no detectable traces of THC, meaning that they are completely legal in the United States and do not have any psychoactive properties. Each of the products that you can buy from Ablis is competitively priced, especially considering the quality and potency of them.

The Lemon Ginger 12 fluid ounce CBD Beverage from Ablis is the product that we most highly recommend from their site for curbing the negative symptoms that depression commonly causes. These CBD beverages contain 25 mg of CBD per 12-ounce bottle. In addition to the numerous mental and physical health benefits that CBD offers, because these zesty beverages contain both lemon and ginger–both natural remedies that are known to help with a variety of problems, including depression and anxiety–you will be getting a very potent remedy for depression, all contained in a delicious drink.

  • Product Types: Topicals, Beverages, Crystals, and Concentrates
  • Our Recommended Product for Depression: Lemon Ginger 12 oz CBD Beverage

Serene CBD

Serene CBD

Serene CBD was founded in 2016 by Erica Valker and is dedicated to providing their customers with the highest-quality CBD products that are available on the market today. Founder Erica Valker has stated that her usage of medical cannabis saved her life, back when she was struggling to beat Lyme Disease.

Because cannabis saved her life, she is a strong advocate for medical cannabis and CBD usage for mental and physical well-being. Her views on the many beneficial benefits of medical cannabis and CBD led her to make the decision of helping others by providing them with not only high-quality CBD products but with what she considers to be luxurious CBD products, all while keeping them as affordable as possible in order to have a wide reach.

Serene CBD is strongly committed to using only the best organic and natural ingredients in their products. Additionally, they guarantee that all of their products are free of common allergens such as gluten, corn, and soy in addition to being completely free from any chemicals, pesticides, or other natural contaminants. In fact, Serene CBD utilizes a third-party lab, and they have them test their products for safety, potency, and purity.

Serene CBD also donates $3 from every purchase to the LymeLight Foundation, which is a great non-profit organization that works to raise awareness of Lyme Disease and tirelessly strives to help fund research treatments for the disease, which affects more than 30,000 new people in the United States per year according to the Center for Disease Control (CDC).

The Serene CBD product that we would recommend to those that are dealing with depression would be their CBD Oil Tinctures. These 30 ml /one-ounce bottles contain 600 mg of CBD per bottle, with a full single dose containing approximately 20 mg of CBD (one full dose is a dropper full of CBD oil tincture). These oil tinctures are available in the Original flavor or a Mint flavor, neither of which is too overpowering in their taste. These tinctures contain full-spectrum extracted organic CBD and organic Medium Chain Triglyceride (MCT) oil. Because of the delivery method, the quality of the product and the potency, Serene CBD’s CBD Oil Tinctures are an excellent choice for a fast-acting CBD product that will help mitigate the ill-effects of depression and anxiety.

  • Product Types: Tinctures, Serums, Balms, Vape Cartridges, and Bundles
  • Our Recommended Product for Depression: CBD Oil Tincture


Mellowment Beverage Enhancer

All of Mellowment’s various CBD-dense products are made using CBD that was carefully and expertly extracted from 100% organic and all-natural industrial hemp that is grown using sustainable farming practices on the nutrient-rich soil of Colorado. The extraction method that Mellowment uses ensures that as much of the beneficial properties of the industrial hemp is present for the end-user.

Mellowment is oft-cited as being a very trustworthy manufacturer of high-quality CBD products in large part due to the fact that the company promises to provide its customers with some of the best CBD products on the market, and they promise to continually honor their commitment to always provide their customers with quick and courteous customer service that is provided by their courteous and highly trained customer service team.

Mellowment specializes in softgels and an impressive and highly potent proprietary CBD oil tincture. The CBD products that are offered by Mellowment are considered by many to be some of the best CBD products that can be found on the market today, and they differ from many other CBD products in one key way: all of the bioactive ingredients that are found in their products are nano-emulsified in a proprietary process in order to create a greater amount of water solubility and to enhance these ingredients’ natural bioavailability.

Additionally, each of Mellowment’s CBD-rich products is low THC yield–meaning that there is no detectable THC in the products, making them legal in every state in the United States and ensuring that their customers do not feel any potentially adverse mental effects. The CBD products offered by Mellowment are all third-party laboratory tested for efficacy, potency, purity, and safety to ensure that no matter which product you purchase, you’re guaranteed to be receiving one of the best CBD products that are currently available on the market.

The product from Mellowment that we would recommend to our readers that are suffering from depression, or that may know someone that is suffering from depression, is their awesome CBD Beverage Enhancer. This beverage enhancer provides 1.5 mg of CBD per two drops. It is recommended to use six drops per 6 to 8-fluid-ounce glass to gauge if you would prefer more drops or fewer drops in your drink. Customers commonly use this beverage enhancer in things such as coffee, water, healthy green juices, energy drinks, protein shakes, and tea, among other fan-favorite drinks. Because this enhancer uses CBD that was nano emulsified to make sure that it is easily soluble, allowing the body to be able to make use of its beneficial properties quickly.

  • Product Types: Softgels and Tinctures
  • Our Recommended Product for Depression: CBD Beverage Enhancer

Calm by Wellness

Calm by Wellness Oil

Calm by Wellness Co. is a California-based CBD company that has been featured on NBC, CNN, NPR, FOX and The New York Times among other news programs and sites due to the quality and affordability of their numerous CBD products that are made using CBD that was extracted from 100% organic industrial hemp. Additionally, Calm by Wellness Co. was recently voted as having the best CBD products for pain, sleep, and anxiety according to their company’s website, which is impressive.

For the CBD extract that the company uses in its products, the source only the highest possible grade, organically grown industrial hemp, which is cultivated in the nutrient-rich soil of Colorado’s farmland. The different items that are in their two product lines (CBD extracts and CBD gummies) are all made with Full-Spectrum extracted CBD oil, natural hemp seed oil, fractionated coconut oil (which contains two very beneficial Medium-Chain Triglyceride fatty acids), and a variety of high-quality essential oils, which naturally add a pleasant taste to all of their products.

Calm by Wellness Co. donates a lot of money and resources to various non-profit organizations in order to provide a higher quality-of-life for their communities and people around the world. Because of this commitment to bettering the world through not only their excellent high-quality CBD products–which are very affordable comparatively–but also through their other actions, it is very easy to want to become one of their long-time customers; of which they already have many, all of whom are satisfied with each and every single one of their purchases.

The Hemp CBD Chill Oil Tincture is what we would recommend you trying out for helping with depression. This oil tincture is Chocolate Mint flavored, and is a delicious CBD product. It is specifically designed to give you fast relief and is formulated to help your mind and body to relax. Due to its potency, taste, fast-acting nature, and how it is specifically made to help to ease your worries and relax your muscles, this is an excellent CBD product to try out.

  • Product Types: Extracts and Gummies
  • Our Recommended Product for Depression: Hemp CBD Chill Oil Tincture

Plus CBD

Plus CBD is a Las Vegas, Nevada-based CBD company with only one goal in mind: to provide as many people as possible with affordable, high-quality, and potent CBD-based products in order to enhance their everyday lives by providing them with an increase to their quality of life through better mental and physical health.

With claims of being the top-selling industrial hemp-derived CBD brand on the market today, there are many people worldwide that trust Plus CBD to provide them with a potent, safe, and pleasant CBD experience. Because of Plus CBD’s history, they are a great CBD company for new CBD users and veteran users alike. Whether you just want to try CBD for a short time, or are planning on being a long-term user, Plus CBD has you covered.

Plus CBD has to source their organic industrial hemp from Europe because of the immense scale of CBD that they require to fill all of their customer orders. This EU-sourced industrial hemp is carefully cultivated and harvested in nutrient-dense soil so that the end product is among the best in terms of quality and potency that you can get on the market today.

Plus CBD takes a “From Seed to Shelf™” stance when it comes to their numerous product lines. This means that the experienced and skillful Plus CBD employees are involved in every step of the cultivation and manufacturing process; from when the industrial hemp seeds are first planted in the ground to when the completed product is being packaged and distributed to Plus CBD’s customers.

Plus CBD tests and manufactures their CBD products in a state-of-the-art facility that fully follow the Good Manufacturing Practices (GMP) guidelines that are set by the International Society for Pharmacoepidemiology (ISPE) and are enforced in the United States by the Federal Food, Drug, and Cosmetic Act (FDCA). This ensures that the CBD products produced by Plus CBD are among the safest CBD products on the market.

The product from Plus CBD that we would recommend someone that is suffering from the effects of depression would definitely be their CBD Oil 15 mg Gold Formula Soft Gels. The CBD that is contained in these soft gels is extracted from the aerial parts of the plants and nothing else, thus ensuring a higher amount of quality and purity–in addition to more potency–than some other CBD products that are on the market today. Due to their potency and the very affordable price point, these soft gels are the perfect supplement for better mental health, particularly for those that are dealing with either chronic depression or clinical depression.

  • Product Types: Balm, Spray, Drops, Roll-Ons, Gummies, Capsules, and Soft Gels
  • Our Recommended Product for Depression: CBD Oil 15 mg Gold Formula Soft Gels

Pure Hemp Botanicals

Pure Hemp Lavender Tea

Pure Hemp Botanicals is a Colorado-based company that is solely run on their corporate and personal mantra of “Compassion in Action” on which all of their business decisions are based, no matter how big or small.

Pure Hemp Botanicals only uses locally sourced, cruelty-free, and certified 100% organic industrial hemp from farms that are run by farmers that actually care. They use this high-quality industrial hemp to create their numerous vegan, non-GMO, and 100% organic CBD-based products.

Some of the product lines that Pure Hemp Botanicals sell include: CBD isolate crystals, soft gel capsules, lip balms, CBD vape oil liquids, and a selection of CBD-based pet care products, among others. Pure Hemp Botanicals hold themselves to a very high set of standards and, unlike some other companies that might be out there, they also hold all of their business partners to the same set of standards.

If a company does not continually comply with what Pure Hemp Botanicals requires of them, then the company stops doing business with them. This ensures that the end product that you get when you buy a CBD product from Pure Hemp Botanicals is highly potent, easy on the wallet and is extremely ethical at every step of cultivating and manufacturing processes.

Pure Hemp Botanicals are proud to donate 1% of their total proceeds that come from all purchases of the CBD products to the awesome non-profit organization, Mercy for Animals (MFA). Mercy for Animals is an organization that is dedicated to spreading information about how to make compassionate food choices in your diet, and they heavily advocate the end to inhumane animal farming practices, such as factory farming, where the livestock is kept enclosed in tiny, overcrowded cages. Because of this, buying a CBD product from Pure Hemp Botanicals is sure to make you feel good about your purchase in whole.

Pure Hemp Botanicals’ Hemptealicious™ Chamomile Lavender Pure Hemp Tea is the product that they carry that we highly recommend you try. This relaxing tea works wonders on both the mind and the body. Each of these containers contains eight tea bags, and each tea bag will make a soothing cup of tea. The tea is naturally caffeine-free, is CBD-rich, and has the added healing properties of both chamomile and lavender.

Chamomile and lavender are both known natural remedies for mood problems and anxiety. When you add in the numerous benefits of CBD into the mix, you have a really strong combination for fighting against the negative influences of depression. This tea is really pleasant tasting, calming and potent; just some of the many reasons we think more people should try this tea out for themselves.

  • Product Types: Capsules, CBD Isolate Crystals, Mints, Pet Care Products, Soft Gels, Tea, Topicals, Vape Liquids, and Lip Balm
  • Our Recommended Product for Depression: Hemptealicious™ Chamomile Lavender Pure Hemp Tea

Thank you for your attention. We are glad you are here, and we are glad that you are seeking out products for self-care help.

Depression is a devastating and rampant mental health problem that generally falls into one of two main categories: Major Depressive Disorder or Clinical Depression. Both of these are very common mental health disorders, with a variety of subcategories and causes, such as:

  • Persistent Depressive Disorder: also known as dysthymia, persistent depressive disorder is a depressed mood that lasts for a minimum of two years.
  • Postpartum Depression: occurs when an individual experiences a major depressive episode during pregnancy or after delivery.
  • Psychotic Depression: this occurs when a person has severe depression in addition to some form of psychosis, such as having false fixed beliefs (which are known as delusions) or hearing or seeing things that others cannot hear or see (which are known as hallucinations).
  • Seasonal Affective Disorder: this is characterized by the onset of depression during the winter months in the year.
  • Bipolar Disorder: Bipolar Disorder is different from depression, but it is often included due to the fact that an individual with bipolar disorder will experience episodes of extremely low moods which meet the criteria for major depression (this is called “bipolar depression”).
  • Disruptive Mood Dysregulation Disorder: DMDD is a newly defined diagnosis where a child exhibits signs of extreme irritability, anger, and frequent, intense temper outbursts. DMDD is thought to cause depression and severe anxiety later in life.
  • Premenstrual Dysphoric Disorder: PMDD causes severe irritability, depression, or anxiety in the week or two before your menstrual period starts and is more severe than premenstrual syndrome (PMS).

Understanding the symptoms and warning signs of depression is one of the most important parts of recognizing and dealing with depression in your own life or helping those in your life that are suffering from depression. The symptoms of depression include–but are not limited to–the following:

  • Persistent sad, anxious, or feeling what can be described as an “empty” mood;
  • Feelings of hopelessness or pessimistic moods;
  • Irritability;
  • Frequent feelings of guilt, worthlessness, or helplessness;
  • Loss of interest in hobbies and activities that use to bring you joy;
  • Decreased energy or feeling fatigued;
  • Moving or talking more slowly than normal; acting sluggish;
  • Feeling restless or having trouble sitting still;
  • Difficulty with concentrating, remembering, or being indecisive;
  • Difficulty sleeping, feeling awake in the morning, or oversleeping;
  • Changes in your appetite and/or changes in your weight;
  • Thoughts of death or suicide, thoughts of self-harm, suicide attempts, or general suicide and self-harm ideation and/or;
  • Pain that does not ease with normal treatment.

Depression is a very serious problem that affects a very large percentage of the population both nationally and globally. Dealing with depression can be very difficult, but with proper treatment and care, it can be mitigated or even fully overcome in almost all cases. Nearly seven percent of the American population of adults, which is as many as 16 million people, experience at least one episode of clinical depression in any given year. Around the world, nearly 350 million people will struggle with depression each year and every single year.

Treatment for major depression is usually achieved with a multi-pronged approach. Antidepressant medications are commonly used as the mainline treatment option, but the most effective treatment plans will also include some type of psychotherapy. In addition to therapy and medication, patients that are living with depression often report that they benefit from receiving help from regular support group meetings, getting support from friends and family, supplementing their healthcare plan with alternative therapies, and from general self-care, such as trying to do things that are enjoyable for you or doing something nice for yourself.

Many people might not fully grasp how wide-spread and damaging depression really is. For those that are suffering from depression, they often report a feeling of aloneness–but that’s often not the case in their personal lives, and it is definitely not the case in a global sense. Some facts about depression that might surprise you are:

  • Mood disorders–which include depression–are the third-most-common cause of hospitalization for adults that are between the ages of 18 and 44 in the United States;
  • Depression is the leading cause of disability in the United States for people that are between the ages of 15 and 44;
  • The average age of onset for depression is around 32;
  • About 1.5 percent of the population in the United States struggles with persistent depressive disorder, but only about 60 percent of those same people get treatment of any sort;
  • Women are 70 percent more likely than men to have to deal with depressive episodes;
  • Rates of depression by race or ethnicity demonstrate that approximately 6.4 percent of white Americans are diagnosed with depression as compared to 7.2 percent of the Hispanic population in the United States, and 4.2 percent of black Americans, and;
  • Tragically, nearly 800,000 people die due to suicide around the world each and every single year.

How Can CBD Help with Depression?

According to the National Center for Biotechnology Information (NCBI), there is very strong evidence that CBD has beneficial antidepressant and anxiolytic (anti-anxiety) properties that can greatly reduce the negative impact that depression and anxiety can have on an individual’s life. CBD has an effect on the 5-HT1A neuro-receptors and the CB1 and CB2 neuro-receptors, which are known to play vital roles in how depression affects the mood and thought process.

By supplementing your diet with a CBD-rich product, you will be able to have a more positive mood overall. CBD also can help alleviate chronic pain, a large contributing factor in many people’s depression. Finally, CBD can help you achieve a good night’s rest, which is essential for positive mental health.

Additional Resources: